Chronic Fatigue Syndrome Causes, Symptoms, Diagnosis, Treatment

Chronic Fatigue Syndrome Causes, Symptoms, Diagnosis, Treatment

What is Chronic Fatigue Syndrome?

We all get tired. Many of us at times have felt depressed. But the mystery known as chronic fatigue syndrome is not like the normal ups and downs we experience in everyday life. The early sign of this illness is a strong and noticeable fatigue that comes on suddenly and often comes and goes or never stops. You feel too tired to do normal activities or are easily exhausted with no apparent reason. Unlike the mind fog of a serious hangover, to which researchers have compared Chronic Fatigue Syndrome, the profound weakness of Chronic Fatigue Syndrome does not go away with a few good nights of sleep. Instead, it slyly steals your energy and vigor over months and sometimes years.

The Chronic Fatigue Syndrome Case Definition

The EBV work sparked new interest in the syndrome among a small group of medical researchers. They realized they needed a standard way to describe Chronic Fatigue Syndrome so that they could more easily compare research results. 

Chronic Fatigue Syndrome Causes, Symptoms, Diagnosis, Treatment
Chronic Fatigue Syndrome

In the late 1980s, CDC brought together a group of Chronic Fatigue Syndrome experts to tackle this problem. Based on the best information available at the time, this group published in the March 1988 issue of the scientific journal, Annals of Internal Medicine, strict symptom and physical criteria -- the first case definition -- by which scientists could evaluate Chronic Fatigue Syndrome study patients. 

Not knowing the cause or a specific sign for the disease, the group agreed to call the illness "chronic fatigue syndrome" after its primary symptom. "Syndrome" means a group of symptoms that occur together but can result from different causes. (Today, Chronic Fatigue Syndrome also is known as myalgic encephalomyelitis, postviral fatigue syndrome, and chronic fatigue and immune dysfunction syndrome.) 

After using this definition for several years, Chronic Fatigue Syndrome researchers realized some criteria were unclear or redundant. An international group of Chronic Fatigue Syndrome experts reviewed the criteria for CDC, which led to the first changes in the case definition. This new definition was published in the same journal in December 1994. 

Besides revising the Chronic Fatigue Syndrome case criteria -- which reduced the required minimum number of symptoms to four out of a list of eight possible symptoms -- the newer report also proposed a conceptual outline for studying the syndrome. This outline recognizes Chronic Fatigue Syndrome as part of a range of illnesses that have fatigue as a major symptom. Although primarily intended for researchers, these guidelines should help doctors better diagnose Chronic Fatigue Syndrome.

What Causes Chronic Fatigue Syndrome?

Chronic Fatigue Syndrome Causes, Symptoms, Diagnosis, Treatment
Chronic Fatigue Syndrome

While no one knows what causes Chronic Fatigue Syndrome, for more than a century, doctors have reported seeing illnesses similar to it. In the l860s, Dr. George Beard named the syndrome neurasthenia because he thought it was a nervous disorder with weakness and fatigue. Since then, health experts have suggested other explanations for this baffling illness.
  • Iron-poor blood (anemia)
  • Low blood sugar (hypoglycemia)
  • Environmental allergy
  • A body wide yeast infection (candidiasis)

In the mid-1980s, the illness became labeled "chronic EBV" when laboratory clues led scientists to wonder whether the Epstein-Barr virus (EBV) might be causing this group of symptoms. New evidence soon cast doubt on the theory that EBV could be the only thing causing Chronic Fatigue Syndrome. High levels of EBV antibodies (disease-fighting proteins) have now been found in some healthy people as well as in some people with Chronic Fatigue Syndrome. Likewise, some people who don’t have EBV antibodies, and who thus have never been infected with the virus, can show Chronic Fatigue Syndrome symptoms.

How Chronic Fatigue Syndrome Begins and Its Symptoms

For many people, Chronic Fatigue Syndrome begins after a bout with a cold, bronchitis, hepatitis, or an intestinal bug. For some, it follows a bout of infectious mononucleosis, or mono, which temporarily saps the energy of many teenagers and young adults. Often, people say that their illnesses started during a period of high stress. In others, Chronic Fatigue Syndrome develops more gradually, with no clear illness or other event starting it.

Unlike flu symptoms, which usually go away in a few days or weeks, Chronic Fatigue Syndrome symptoms either hang on or come and go frequently for more than six months. Chronic Fatigue Syndrome symptoms include:
  • Headache
  • Tender lymph nodes
  • Fatigue and weakness
  • Muscle and joint aches
  • Inability to concentrate

Who Gets Chronic Fatigue Syndrome?

Chronic Fatigue Syndrome was once stereotyped as a new "yuppie flu" because those who sought help for and caused scientific interest in Chronic Fatigue Syndrome in the early 1980s were mainly well-educated, well-off women in their thirties and forties. Similar illnesses, known by different names, however, date back at least to the late 1800s. The modern stereotype arose. Since then, doctors have seen the syndrome in people of all ages, races, and social and economic classes from several countries around the world. 

Still, Chronic Fatigue Syndrome is diagnosed two to four times more often in women than in men, possibly because of biological, psychological, and social influences. For example,
  • Chronic Fatigue Syndrome may have a gender difference similar to diseases such as systemic lupus erythematosus and multiple sclerosis, which affect more women than men.
  • Women may be more likely than men to talk with their doctors about Chronic Fatigue Syndrome-like symptoms.
  • Some members of the medical community and the public do not know about or are skeptical of the syndrome.
  • An increasingly diverse patient group will likely emerge as more doctors see Chronic Fatigue Syndrome as a real disorder.

How Can I Cope With and Manage the Illness?

Chronic Fatigue Syndrome Causes, Symptoms, Diagnosis, Treatment
Chronic Fatigue Syndrome

There is no effective treatment for Chronic Fatigue Syndrome. Even though there is no specific treatment for Chronic Fatigue Syndrome itself, you may find it quite helpful to treat your symptoms. Nonsteroidal anti-inflammatory drugs, such as ibuprofen, may help get rid of any body aches or fever, and nonsedating antihistamines may help relieve any prominent allergic symptoms, such as runny nose. 

Learning how to manage your fatigue may help you improve the level at which you can function and your quality of life despite your symptoms. A rehabilitation medicine specialist can evaluate and teach you how to plan activities to take advantage of times when you usually feel better. 

The lack of any proven effective treatment can be frustrating to both you and your doctors. If you have Chronic Fatigue Syndrome, health experts recommend that you try to maintain good health by:
  • Eating a balanced diet and getting adequate rest
  • Exercising regularly but without causing more fatigue
  • Pacing yourself -- physically, emotionally, and intellectually -- because too much stress can aggravate your symptoms.The course of Chronic Fatigue Syndrome varies from patient to patient
For most people, Chronic Fatigue Syndrome symptoms plateau early in the course of illness and thereafter wax and wane. Some people get better completely, but it is not clear how frequently this happens. Emotional support and counseling can help you and your loved ones cope with the uncertain outlook and the ups and downs of this illness. 

New studies seem to show that cognitive behavioral therapy and graduated exercise programs can greatly help many. Others are helped by antidepressants.

Because well-designed clinical studies have found that patients with fibromyalgia (an illness similar to Chronic Fatigue Syndrome) benefit from low-dose tricyclic antidepressants, doctors often prescribe these drugs for people with Chronic Fatigue Syndrome with generally positive results. Some researchers believe that these drugs improve the quality of sleep. Patients also have benefited from other kinds of antidepressants, including the newer serotonin reuptake inhibitors. Therapeutic doses of antidepressants often increase fatigue in Chronic Fatigue Syndrome, so doctors may have to increase the dosage very slowly, or prescribe more active antidepressants. In addition, some people with Chronic Fatigue Syndrome benefit from the benzodiazepines, a class of drugs used to treat acute anxiety and sleep problems. Patients often try more than one drug before finding one that works and can be tolerated.


Chronic Fatigue Syndrome seems to involve interactions between the immune and central nervous systems, interactions about which scientists know relatively little. Scientists' concerted efforts to penetrate the complex nervous system and immune system events in Chronic Fatigue Syndrome have created a challenging new concept of the pathology of this and other illnesses.