Leukemia stem cell treatment in Vietnam

Leukemia stem cell treatment in Vietnam

Dr. Nguyen Anh Tri, Director of the Institute of Hematology and Blood Transfusion Committee for more information about the conduct of fellow marrow (or stem cells) to treat blood cancer ...

Dr. Nguyen Anh Tri, Director of the Institute of Hematology and Blood Transfusion Center (Photo: Ngoc Huyen)

On 25/5, Institute of Hematology and Blood Transfusion Committee has conducted a bone marrow transplant (also called stem cells) for a 21-year-old girl with leukemia (blood cancer). Main methods used immune competent stem cells to destroy the malignant cells initially gave positive results ... Bo reporter had an interview with Dr. Nguyen Anh Tri, Director of the Central Institute of Hematology and Blood Transfusion about this new method of treatment.



- It is known that the Central Institute of Hematology and Blood Transfusion is the first stem cell transplant method marrow kill at least in recent bone marrow transplant ... This method is nothing new compared to the previous method?

- Most of the methods of stem cell transplant at the hospital to kill the maximum marrow. But. The Institute used the original immune competent cells to destroy the malignant cells, do not use strong chemicals. This approach to health, liver, spleen, kidney, and all other organs of the patient is not compromised too much.

It is the second new stem cell transplant patients, we obtained from peripheral blood. Ever, and the world, especially in the U.S., mostly stem cells taken from bone marrow. Want to get the stem cells, to about 300-400ml of bone marrow aspirate from the pelvis, sternum ... and transmitted to the patient. For amounts above stem cell donor or patient takes hundreds of needles poked in the body; after the get finished marrow, and can be very painful.




- Can you tell us, so far, the situation of the patient's health has been a bone marrow transplant?

- To date, clinical health status of patients with completely normal, better than before transplantation. Patients with no fever, eating, normal activities, the blood tests are very good. The good news is that the blood cells began to develop in the grafted cells. The number of leukocytes of patients increased to 1 x 109/lit compared with the beginning of treatment (0). According to our prognosis, the result of about 90% of transplants. However, we remain vigilant and continue to monitor.



- For this new method marrow transplant, patients must meet the conditions for what, sir?

- The conditions for stem cell transplant patients were young (21 years old); patients were chemotherapy and reduce some malignant cells; health can meet and stem cell donors accordingly. Bowel patients are fortunate to have my sister (23 years old) with HLA (test stem cells in the blood), 6 genes necessary fit and the same blood group O.


- Could you describe the preliminary steps of the same kind of stem cell transplant patient has done above?


For the donor stem cells, we used a drugs blood cells for 5 days produced stem cells and peripheral blood. Then, we use a special machine with centrifugal system to separate stem cells, and other blood components back to the body. With this method, the donor stem cells do not have pain, not annoying and save. Of stem cells need to get 400-450ml and we transplant carried out in two days.
- First, health checks Institute, the liver, kidneys, blood marrow, malignant cells, and it's 

appropriate for the recipient, fungal tests and test all types of viruses to prognosis changes.
For recipients, patients treated immunosuppressive drugs to destroy malignant cells, then transfer stem cells and drugs stimulate blood. We have a professional team work and most of the tests were conducted at the hospital. In recent years, the Central Institute of Hematology and Blood Transfusion has sent some officials to the United States health center for daily training and consultation with other doctors to monitor the situation.


- Institute of anticipated complications, side effects happen after transplantation, sir?

- We have used inhibitors of this phenomenon. So far, in addition to the above reaction patients without any side effects. Other complications we prognosis, prevention and patient are in the process to be monitored closely.



- For this new method marrow transplant, patients must meet the conditions for what, sir? How much is cost for a marrow transplant?

- The conditions for stem cell transplant patients were young (21 years old); patients were chemotherapy and reduce some malignant cells; health can meet and stem cell donors accordingly. In marrow transplant on 25/5, so this is the first transplant should institute has no specific calculations, estimated at about 550-700 million. However, patients in the Institute to support the entire cost of transplant.
Currently, in the U.S. stem cell transplant to treat this disease is usually sent to Singapore with a price of not less than $ 50,000 (equivalent to approximately 900 million). So, after the success of stem cell transplantation, we will extend the treatment in the country.


- Thank you!
According Chuaungthu.net